A constituent unit of Shri Dharmasthala Manjunatheshwara University
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Assistant Professor
| Dr. Ajay S K is a distinguished researcher and academician with nearly 15 years of experience in biochemistry and molecular biology. His expertise includes anticancer drug discovery, drug-DNA interactions, small molecule screening, and preclinical and clinical studies focusing on cancer and PCOS. His research extends to understanding the role of gut microbiota in metabolic disorders and evaluating therapeutic interventions. |
| He specializes in protein and enzyme purification, chromatographic techniques, mammalian cell culture, Western blotting, PCR, and microbial culture. He is also skilled in clinical sample analysis for personalized drug development and correlation studies. |
| Dr. Ajay has an extensive publication record in high-impact journals and has presented his findings at national and international conferences. He has worked on projects involving computational drug discovery, radioprotective agents, and nanotechnology-based drug delivery. His scientific writing skills include regulatory medical writing, proposal development, and manuscript preparation. |
Ph.D. Scholar/Projects Fellows/Trainees
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| Currently working in SDM Research Institute for Biomedical Sciences, Shri Dharmasthala Manjunatheshwara University, Dharwad as Assistant Professor from March 2020. |
| Assistant Professor, College of Fisheries, KVAFSU, Mangalore from June 2014 to March 2020 |
| Guest Lecturer, Davangere University, (Department of Biochemistry), Davangere, India from June 2013 to May 2014 |
| Guest Lecturer, Mangalore University, (Department of Biochemistry), Madikeri, India from August 2012 to May 2014 |
| Guest Lecturer, St. Aloysius College, Mangalore from December 2008 - May 2009 |
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| In-vitro & in-vivo evaluation of pharmacological properties & anticancer of natural products-Ayurveda & Marine sources. |
| Experience in performing Protein & Enzyme Purification using various techniques including Size Exclusion Chromatography, Ion Exchange Chromatography, Affinity Chromatography Technique. |
| Development of patient tissue-derived primary cell cultures & cell-based assay for drug screening & toxicological studies. |
| The Intricate relationship between Gut microbiota & Pancreatic health & diseases-experimental & clinical approaches to untie the interaction between pancreas & gut microbiota. |
| Co-guide for Ph.D thesis entitled "Correlation of serum & tissue expression status of leptin & adiponectin & it's receptors with respect to clinico pathological parameters in early & metastatic colorectal carcinomas" |
| Khandagale, A. S., Sarojini, B. K., Kumari, S. N., Joshi, S. D. S., & Nooralabettu, K. (2015). Isolation, Purification and Biochemical Characterization of Trypsin from Indian Mackerel (Rastralliger Kanagurta). Journal of Aquatic Food Product and Technology, 24(4), 354-367. |
| Nivya, M. T., Patil, R. K., Advirao, G. M., Khandagale, A. S., Somashekrappa, H. M., Ananda, D., Manjunath, H. M., & Joshi, C. G. (2019). Cytotoxicity Based Screening for Radio Protective Properties of Methanolic Extracts of Tragia Involucrata L. on Cultured Human Peripheral Lymphocytes Exposed to Gamma Radiation. Indian Journal of Experimental Biology, 57, 469-477. |
| Thimmaiah, N. M., Joshi, C. G., Patil, R. K., Khandagale, A. S., Somashekarappa, H. M., Ananda, D., & Manjunath, H. M. (2019). Mitigation of Radiation-Induced Oxidative Stress by Methanolic Extract of Tragia involucrata in Swiss Albino Mice. Pharmacognosy Research, 11(3), 237-243. https://doi.org/10.4103/pr.pr_177_18 |
| KiranKumar, H. N., RohitKumar, H. G., Khandagale, A. S., & Advirao, G. M. (2021). In vivo Antitumor, Pharmacological and Toxicological Study of Pyrimido[4′,5′:4,5]thieno(2,3-b)quinoline with 9-hydroxy-4-(3-diethylaminopropylamino) and 8-methoxy-4-(3-diethylaminopropylamino) Substitutions. Anti-Cancer Agents in Medicinal Chemistry, 21(17), 2419-2428. https://doi.org/10.2174/1871520621666210208175609 |
| Abhilash, N., Khandagale, A. S., Ramesh, K. V., & Math, R. K. (2022). Lasiosiphon glaucus a potent ethnobotanical medicinal plant against breast cancer targeting multiple pathways: An in vitro study. Advances in Traditional Medicine. https://doi.org/10.1007/s13596-021-00624-0 |
| Pratap, K., Yalpi, K., Poornima, D. V., Raghavendra, H. L. S., Khandagale, A. S., Ashok, P., Sathisha, J. G., Ali, A. M., Abdulrahman, A., Samy, S. S., Manjula, S., & Muntazir, M. (2023). In vitro evaluation of the neuroprotective potential of Olea dioica against Aβ peptide-induced toxicity in human neuroblastoma SH-SY5Y cells. Frontiers in Pharmacology, 14, 1139606. https://doi.org/10.3389/fphar.2023.1139606 |
| Parmesh, P., Shastri, D. U., Goni, M., Bargale, A. B., & Khandagale, A. S. (2024). mRNA expression profiling of leptin and adiponectin and its receptors in colorectal carcinoma – Biomarker development. Advances in Cancer Biology – Metastasis, 10. https://doi.org/10.1016/j.adcanc.2024.100118 |
| Parmesh, P., Shastri, D. U., Khandagale, A. S., Bargale, A. B., Sadashiv, R., & Reddy, P. (2024). Correlation of leptin and adiponectin receptor expression with clinicopathological parameters in colorectal carcinoma – A cross-sectional prospective study. Arquivos de Gastroenterologia, 61, e24016. https://doi.org/10.1590/S0004-2803.24612024-016 |
| Padakannaya, A., Poyya, J., Patel, J. I. A., Kurdekar, N. M., & Khandagale, A. S. (2025). Computational discovery of potential human carbonic anhydrase IX inhibitors. Journal of Biomolecular Structure and Dynamics, 2025, 1-13. https://doi.org/10.1080/07391102.2025.2472395 |
| Patel, J. I. A., Poyya, J., Padakannaya, A., Kurdekar, N. M., Khandagale, A. S., Joshi, C. G., Kanade, S. R., & Satyamoorthy, K. (2025). Mechanistic insights into gut microbe-derived siderophores and PHD2 interactions with implications for HIF-1α stabilization. Scientific Reports, 15, 1113. https://doi.org/10.1038/s41598-024-83730-8 |
| "Role of Microbes & Enzymes for Next Generation Biodiversity & its New Study Tool" at National level seminar on "Biodiversity: An endless exploration" held on 22nd February 2010 at St. Aloysius College, Mangalore; won Best Oral Presentation Award. |
| "Isolation & Characterization of Gut Bacteria with Antimicrobial & Antioxidant Potential from Shrimp Culture Environment" at International Conference on "Current Concepts on the Role of Indian Medicine & Phytoceuticals in Maintenance of Health" by IABMS & Mangalore University 39th Conference on 15 to 17th November 2018; won Best Oral Presentation Award |