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Dr. Palaksha K. Javaregowda

Home About Faculty Dr. Palaksha K. Javaregowda

Dr. Palaksha
Dr. Palaksha K. Javaregowda

Professor

  • +91 8362477334/6/7 Mobile Number
  • palakshakj@sdmuniversity.edu.in Email Address
20 Years
Experience
21
Projects
56
Publications
He obtained his graduation & postgraduation in Fisheries Science and Ph.D. in Veterinary Medicine majoring in Immunology. During his post-graduation, he worked on the development of rapid diagnostic kits and vaccines for aquatic animal pathogens in India and South Korea. In my post-doc, he worked on the effect of tryptophan metabolites on collagen-induced arthritis using mouse model; generation and use of iPSCs (bovine, porcine, mouse, and human) as donor cells for SCNT (bovine & porcine) and rejuvenating aged oocytes (mouse); and melanocytic & hepatic differentiation of hiPSC/hESCs to develop cell therapy products and drug metabolism/toxicity models. During the past decade, he has been working with eminent scientists and clinicians from South Korea, Japan, United Kingdom and India to develop cell/stem cell therapy products to treat orthopaedic disorders, liver disease and 3D cell culture systems for drug metabolism and toxicity studies.
Currently, he is involved in investigating the role of nutrition, metabolites and microbiota/microbiome on human health and disease, he is particularly interested in exploring the potential implications of nutrition and microbiota on fertility, development and regeneration of tissues/organs. From a preventative and/or regenerative medicine perspective, his aim is to develop nutritional interventions that mimic the metabolic effects of diets which augment the healthy gut microbiota, immune function, fertility, normal development, tissue healing and regeneration without leading to any abnormalities. As well, his team is working on the development of cell & cell-based products and assays to improve individualised healthcare of the local population. He has active projects investigating the role of human microbiota in fertility/subfertility and establishment of in-house procedures to replace the xenogeneic source of growth supplements to isolate and culture human tissue derived cells in vitro for clinical applications.
In addition, he has experience of teaching Immunology, Nutritional Immunology, Stem Cell Biology, Stem Cells & Regenerative Medicine, Proteomics, Microbiology, Virology, Biomedical Applications of Nanotechnology, Basics of Human Genetics, and Ethics in Biomedical Research & Nursing practice courses to graduate & post-graduate students. Moreover, he has worked with multiple companies as a researcher & manager of R&D division and technical advisor for designing and construction of research laboratories and clean rooms in India and abroad. He also served as a member in various capacities in academia, administration and industry for more than 22 years.
He has extensive experience in setting up research laboratories & institutes, contributing to the advancement of biomedical sciences & translational applications. One notable experience is his current role at Shri Dharmasthala Manjunatheshwara University in Dharwad, India. As part of this responsibility, he played a crucial role in planning & establishing the Research Institute for Biomedical Sciences, a constituent unit of the university. This involved designing the syllabus for Master & Ph.D programs in Biomedical Sciences & organizing training programs for laboratory techniques & cell culture techniques. His expertise in establishing research infrastructure & creating an environment conducive to advanced research, teaching, & training has been invaluable.
In addition, he has contributed to the setup of various research centers & laboratories in different organizations. In Bengaluru, Karnataka, India, he was involved in designing a basic research laboratory & a clean room facility for private organizations. This required careful planning & attention to detail to ensure the proper setup of essential laboratory equipment & the maintenance of a clean & controlled environment necessary for conducting advanced research.
Furthermore, he played a key role in designing & establishing the Biomedical Research Center at SDM College of Medical College & Hospital in Dharwad, India. This center was dedicated to advanced biomedical research & translational applications, aiming to bridge the gap between scientific discoveries & their practical implementation in healthcare. His contribution to creating the infrastructure & ensuring the availability of state-of-the-art research facilities was instrumental in facilitating cutting-edge research in the field of biomedical sciences.
He also had the opportunity to establish the Stem Cell Research & Regenerative Medicine Centre at K. S. Hegde Medical College, Nitte (Deemed to be University) in Mangaluru, India. This center focused on harnessing the potential of stem cells & regenerative medicine for addressing various human diseases & conditions. His expertise in setting up the necessary infrastructure & ensuring the compliance with regulatory standards played a crucial role in establishing a center dedicated to cutting-edge research in the field.
Moreover, he has experience in setting up specific research units within larger research organizations. For example, at the Cardiovascular & Metabolic Disease Centre, Inje University in Gimhae, South Korea, he set up the Proteomics Research Unit. This involved establishing the necessary infrastructure, including specialized equipment & resources, to enable in-depth proteomic research aimed at understanding the role of proteins in cardiovascular & metabolic diseases.
Additionally, he contributed to the establishment of an R&D laboratory at Phikon Biotech Pvt. Ltd. in Bengaluru, India. In this role, he was responsible for setting up the laboratory & ensuring its functionality to support research & development activities. This required careful planning & coordination to equip the laboratory with the necessary instruments, materials, & protocols to facilitate effective research in the biotechnology field.
Through his experiences in setting up research laboratories & institutes, he has demonstrated his expertise in designing & establishing research infrastructure, ensuring compliance with regulatory standards, & creating an environment conducive to cutting-edge research & innovation. His contributions have been pivotal in advancing biomedical sciences & facilitating translational applications for the benefit of scientific & medical communities.
Further, He brings extensive teaching experience in various subjects, both at undergraduate & master's levels. At SDM Research Institute for Biomedical Sciences (SDMRIBS) & National Center for Child Health & Development in Tokyo, Japan, he taught Stem Cells & Regenerative Medicine for a period of two years each. His expertise in the field of nutritional immunology was utilized during his teaching tenure at SDMRIBS for two years as well.
In the realm of immunology & proteomics/immunoproteomics techniques, he shared his knowledge & conducted lab sessions at Cardiovascular & Metabolic Disease Centre, Inje University in Gimhae, South Korea, for two years. Additionally, he taught at the Department of Veterinary Medicine, Gyeongsang National University (GNU) in Jinju, South Korea, for three years, covering subjects such as immunology & proteomics/immunoproteomics techniques. His teaching responsibilities encompassed a diverse range of techniques, including sample preparation for chromatography, 2-DE & MALDI-TOF/MS analysis, iso-electric focusing (IEF), 2-DE & 2D-immunoblot, immunological assays, virus purification, & antibody production.
Furthermore, he has contributed to the field of aquaculture biotechnology & fish & shellfish nutrition as a teacher at the College of Fisheries, University of Agricultural Sciences (UAS) in Bengaluru. He conducted classes & lab sessions focusing on immunological assays, virus purification, & antibody production in the context of aquaculture biotechnology.
Through his teaching experience, he has demonstrated his ability to effectively convey complex concepts & methodologies to students at different educational levels. His diverse range of subjects & hands-on laboratory sessions reflect his comprehensive understanding of the respective fields.
He has conducted research in various areas, showcasing his diverse scientific expertise. One of his ongoing research focuses on the human microbiome/microbiota & its role in health & disease. Specifically, he is currently investigating the gut microbiome & its interactions with the gut-liver, gut-brain, gut-pancreas, & reproductive axis. Additionally, he is involved in translational glycobiology research, aiming to understand the impact of microbiome/microbiota on human health & diseases.
In the field of regenerative medicine, he has been involved in multiple projects. One ongoing project involves evaluating the efficacy of pooled human platelet lysate as a replacement for animal serum in the culture of clinical-grade chondrocytes. He has also explored practical applications of regenerative medicine through collaboration with the Japan Agency for Medical Research & Development (AMED). Furthermore, he has investigated aging-associated mitochondrial damage & rejuvenation in advanced reproductive age females & worked with international collaborators to develop regenerative therapies for orthopedic disorders.
Stem cells & cell biology are another area of his research expertise. He has established human embryonic stem cell-derived hepatocytes for in vitro disease & toxicological models, as well as cell therapy. Additionally, he has developed protocols for hepatic spheroid culture & generated hESC-derived melanocytes. His work also extends to the generation & characterization of mouse-induced pluripotent stem cells (iPSCs) & bovine iPSCs for applications in establishing bovine embryonic stem cells & transgenic cattle production.
In the field of rheumatology, he has investigated the prophylactic & therapeutic effects of L-kynurenine & melatonin on collagen-induced arthritis in mice. Furthermore, he has conducted research in immunology, including the characterization of non-specific protective substances from the skin mucus of olive flounder & the study of dietary supplementation effects on disease resistance in freshwater prawns.
His research contributions also encompass the development of immunoassays & biological assays. He has worked on the development of immunodot kits for the detection, prognosis, & diagnosis of viral diseases in shrimp & Red Sea Bream. Additionally, he has conducted evaluations of gonadotropins, newly developing API/drugs, & heavy metal toxicity.
In the field of microbiology, he has identified major antigenic proteins of various pathogens, including Salmonella typhimurium, RSIV, Neospora caninum, & Toxoplasma gondii tachyzoites. He has also conducted pathogenicity evaluations of Lactococcus garvieae in Black Rockfish & developed 2D gel electrophoresis reference maps of pathogenic bacteria.
Furthermore, he has engaged in proteomics & immunoproteomics research, focusing on the development of reference maps & the identification of potential vaccine candidates for pathogenic bacteria. Cryobiology is another area of his expertise, where he has conducted research on the cryopreservation of endangered Mahseer (Tor khudree) spermatozoa. Additionally, he has been involved in antibody production using hybridoma technology, producing monoclonal & polyclonal antibodies against various targets.
Overall, his research efforts encompass a wide range of scientific disciplines, demonstrating his versatility & commitment to advancing knowledge in multiple fields of study.
Akihiro Umezawa, Akinari Fukuda, Reiko Horikawa, Hajime Uchida, Shin Enosawa, Yoshie Oishi, Naoko Nakamura, Kengo Sasaki, Yusuke Yanagi, Seiichi Shimizu, Toshimasa Nakao, Tasuku Kodama, Seisuke Sakamoto, Itaru Hayakawa, Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Palaksha Kanive Javaregowda, Masashi Toyoda, Hidenori Nonaka, Kazuaki Nakamura, Yoshikazu Ito, Yasuyuki Fukuhara, Osamu Miyazaki, Shunsuke Nosaka, Kazuhiko Nakabayashi, Chizuko Haga, Takako Yoshioka, Akira Masuda, Takashi Ohkura, Mayu Yamazaki-Inoue, Masakazu Machida, Rie Abutani-Sakamoto, Shoko Miyajima, Hidenori Akutsu, Yoichi Matsubara, Takashi Igarashi and Mureo Kasahara. (2025). First-in-human clinical study of an embryonic stem cell product for urea cycle disorders. Stem Cell Research & Therapy, 16, 120, 1-11. https://doi.org/10.1186/s13287-025-04162-3 (IF:7.1) [Scimago, Q1].
Chie Kobori, Ryo Takagi, Ryo Yokomizo, Sakie Yoshihara, Mai Mori, Hiroto Takahashi, Palaksha Kanive Javaregowda, Tomohiko Akiyama, Minoru S. H. Ko, Kazuo Kishi, and Akihiro Umezawa. (2023). Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3. Stem Cell Research & Therapy, 14, 1, 242-252 https://doi.org/10.1186/s13287-023-03479-1. (IF:7.1) [Scimago, Q1].
Miyata Shoko, Saku Noriaki, Saeko Akiyama, Javaregowda Palaksha Kanive, Ite Kenta, Nagisa Takashima, Toyoda Masashi, Kei Yura, Kimura Tohru, Nishina Hiroshi, Nakazawa Atsuko, Kasahara Mureo, Nonaka Hidenori, Kiyono Tohru, and Umezawa Akihiro. (2022). Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI). Stem Cell Research & Therapy, 13, 1, 1-12. DOI: 10.1186/s13287-021-02680-4 (IF:7.1) [Scimago, Q1].
Ruri Tsuneishi, Noriaki Saku, Shoko Miyata, Saeko Akiyama, Palaksha Kanive Javaregowda, Kenta Ite, Nagisa Takashima, Masashi Toyoda, Tohru Kimura, Masahiko Kuroda, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Akihide Kamiya, Tohru Kiyono, Junji Yamauchi, and Akihiro Umezawa. (2021). Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells. Scientific Reports, 11, 1, 11381. DOI: https://doi.org/10.1038/s41598-021-90708-3 (IF:4.6) [Scimago, Q2].
Huh SW, Shetty AA, Kim JM, Cho ML, Kim SA, Yang SY, Kim YJ, Palaksha KJ, Choi NY, Kang J, and Kim SJ. (2016). Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of knee. Tissue Engineering and Regenerative Medicine, 13, 2, 200-209. DOI:10.1007/s13770-016-9125-y (IF:4.4) [Scimago, Q2].
Kim SJ, Ok Jae Koo OJ, Park HJ, Moon JH, da Torre BR, Palaksha KJ, Kang JT, Park SJ, Saadeldin IM, Choi JY, Lee BC and Jang G. (2014). Oct4 overexpression facilitates proliferation of porcine fibroblasts and development of cloned embryos. Zygote, 2, 1-8. DOI:10.1017/S0967199414000355 (IF:1.7) [Scimago, Q4].
Jung TS, Del Castillo CS, Palaksha KJ, Dalvi RS, Nho SW, Park SB, Jang HB, Cha IS, Sung HW, Hikima JI and Aoki T. (2012). Seasonal variation and comparative analysis of non-specific humoral immune substances in the skin mucus of olive flounder (P. olivaceus). Developmental & Comparative Immunology, 38, 2, 295-301. DOI:10.1016/j.dci.2012.06.005 (IF:2.7) [Scimago, Q3]
Palaksha KJ, Shin GW, Kim YR and Jung TS. (2008). Evaluation of non-specific immune components from the skin mucus of olive flounder (Paralichthys olivaceus). Fish & Shellfish Immunology, 24, 4, 479-488. DOI:10.1016/j.fsi.2008.01.005 (IF:4.1) [Scimago, Q1].
Patil R., Palaksha KJ, Anil TM, Guruchannabasavanna, Patil P, Shankar KM, Mohan CV and Sripada A. (2008). Evaluation of an immunodot test to manage white spot syndrome virus (WSSV) during cultivation of the giant tiger shrimp Penaeus monodon. Diseases of Aquatic Organisms, 79, 157-161. DOI:10.3354/dao01884 (IF:1.4) [Scimago, Q2]
Shin GW, Palaksha KJ, Kim YR, Nho SW, Heo GJ, Park SC and Jung TS. (2007). Application of immunoproteomics in developing S. iniae vaccine for olive flounder (Paralichthys olivaceus). Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 849, 1-2, 315-322. DOI:10.1016/j.jchromb.2006.11.009 (IF:2.8) [Scimago, Q2]
He has received several prestigious fellowships & awards throughout his career, recognizing his contributions & accomplishments in the field of research. As a Researcher/Research Scientist, he was awarded a Japanese Government job at the National Centre for Child Health & Development in Tokyo, Japan, where he worked for two years. In addition, he received a fellowship for intensive practical training on the generation & characterization of human disease-specific induced pluripotent stem cells (iPSCs) at the same institution.
He further enhanced his expertise through a fellowship for intensive training on cell therapy, GMP guidelines, & quality control of cell-based products at the Catholic Institute of cell therapy, affiliated with the Catholic University of Korea in Seoul, South Korea, where he spent four weeks. As part of his academic journey, he received a Post-doc Fellowship under the Brain Korea 21 (BK-21) project at Seoul National University (SNU) & a Senior Post-doc Fellowship under the Bio-Green project at Inje University, both supported by the South Korean government.
His excellence in presenting research findings was acknowledged with the Excellent Oral Presentation Prize at a conference organized by the Korean Society of Veterinary Science in South Korea in 2006. He was also recognized with the Best Poster Presentation Prize at the VI Symposium on Diseases in Asian Aquaculture, organized by the Fish Health Section of the Asian Fisheries Society in Sri Lanka in 2005. In support of his participation in the symposium, he received Student Travel Assistance.
During his academic pursuits, he was awarded a Ph.D Fellowship by the Korea Science & Engineering Foundation (KOSEF), a government agency of Korea, to pursue his doctoral studies at the College of Veterinary Medicine, Gyeongsang National University in Jinju, South Korea. Additionally, he has received other fellowships, including a Research Fellowship & a Studentship, supported by the Department of Biotechnology (DBT), Government of India, for his research work in aquaculture & microbiology at the College of Fisheries in Mangalore, India.
Notably, he served as an Assistant Director of Fisheries in the Department of Fisheries, Government of Karnataka, India, as part of a gazetted officer job. This appointment further exemplifies his recognition & involvement in governmental roles related to fisheries.
Through these fellowships & awards, he has demonstrated his dedication to research, academic excellence, & contribution to the scientific community, furthering his expertise & accomplishments in his respective fields.
Additionally, He has achieved significant recognition & made valuable contributions through his involvement in various academic & research committees. As the Chairperson of the Faculty of Research in Biomedical Sciences at Shri Dharmasthala Manjunatheshwara University, he has provided leadership & guidance in promoting research excellence. Additionally, he has served as a Scientific Member of the Central Ethics Committee for Studies involving Human Participants, ensuring ethical standards in research involving human subjects.
His commitment to quality assurance in education is evident through his membership in the Internal Quality Assurance Cell (IQAC) of the university. He has also been actively engaged in collaborative efforts, serving as a member of committees working with prestigious institutions such as MAHE, Manipal, & IIT, Madras, to foster collaborations & memorandum of understanding (MoU) initiatives.
In terms of administrative responsibilities, he has undertaken important roles as the Member of the Monitoring Cell for Prohibition of Ragging, contributing to the creation of a safe & respectful educational environment. He has also served on committees related to medals/awards, the preparation of the university's vision document, & the University Executive Committee, where he has played a crucial part in shaping the institution's policies & direction.
Furthermore, his expertise has been recognized beyond his own institution. He has been appointed as an External Examiner for doctoral thesis evaluation at Nitte University, showcasing his reputation as a knowledgeable & respected academic. As the Chairman of the Multidisciplinary Research Advisory Committee at Karnataka Institute of Medical Sciences (KIMS), he has provided valuable insights & guidance to promote interdisciplinary research endeavors.
In addition, he has been actively involved in various other committees related to research, academia, & institutional ethics. These include the Research & Innovation Council, the Academic Council, the Ph.D Committee, the Standing Committee of the Academic Council, & the Research Advisory Committee of SDM Educational Society®. His expertise in ethical research practices is evident through his roles as an institutional member & CPCSEA nominee in the Institutional Animal Ethics Committee & as the Member Secretary of the Institutional Biosafety Committee at Nitte (Deemed to be University).
Overall, his achievements in serving on numerous committees highlight his dedication to academic excellence, research ethics, & the advancement of higher education. Through his active participation & leadership roles, he has made significant contributions to the academic & research community.